Question

The tablet is the most common form for the administration of a drug in a dry state. A tablet shows definite properties of mechanical strength and is characterized by a definite rate of disintegration with water. It is observed that tablets can be made from certain drugs, even without addition of auxiliary substances. But for some drugs, the addition of auxiliary substances is found to be necessary to overcome certain difficulties in their tabletting. The application of different pressure during tabletting plays a very important role. It helps to avoid unnecessary complications. Tablets which should dissolve in the mouth, must be more strongly compressed than other tablets for internal administration. Another important effect of higher pressures is an increase in friction, which demands the use of greater amounts of lubricants and glidants. Glidants are added to the tablets to improve their flow properties.

Answer 1

Таблетка -- наиболее распространённая форма применения лекарства в сухом виде.

Таблетка имеет чётко выраженные свойства механической прочности и характеризуется определённым показателем растворимости в воде.

Можно заметить,что таблетки могут быть изготовлены из одного лекарства,даже без добавления вспомогательных веществ.

Но для некоторых лекарств добавление вспомогательных веществ необходимо для преодоления определённых трудностей в их таблетировании.

Применение различного давления во время таблетирования играет очень важную роль. Оно помогает избежать ненужных сложностей. Таблетки,которые должны растворяться во рту,должны быть сжаты сильнее,чем другие для внутреннего применения.

Другой важный эффект сильного сжатия -- увеличение трения,которое требует использования большего объёма смазывающих веществ и веществ,обеспечивающих лучшее скольжение (глидантов). Глиданты добавляются для улучшения реологических свойств таблеток.

Answer 2

Tablets are a commonly used form for administering drugs in a dry state. They possess specific mechanical strength and exhibit a predictable rate of disintegration when in contact with water. While some drugs can be compressed into tablets without the need for additional substances, others require auxiliary substances to address certain challenges during the tabletting process.

The application of varying pressures during tabletting is crucial as it helps prevent unnecessary complications. For instance, tablets designed to dissolve in the mouth need to be compressed more strongly compared to tablets intended for internal administration. This ensures that the oral-disintegrating tablets maintain their structural integrity until they come into contact with saliva.

Another notable effect of higher pressures is an increase in friction between the tablet formulation and the equipment surfaces. This heightened friction necessitates the use of greater quantities of lubricants and glidants. Lubricants are substances added to tablets to minimize friction and prevent sticking or adherence to the tabletting machinery, while glidants improve the flow properties of the tablet formulation.

Overall, the tabletting process involves careful consideration of the drug's characteristics and the desired mode of administration. Auxiliary substances, such as lubricants and glidants, are employed when necessary to overcome challenges and ensure the production of high-quality tablets with appropriate mechanical strength and disintegration properties.