Question

Глаукома успадковусться декількома ипляхами. Одна i форм визначаеться домінантним зу- тосомним геном, iнша рецесивним також дутосомним, не зчепленим з попередиім геном. a) Яка вірогідність народжения дитини з аномалсю у випадку, якщо обос батьків гете- розиготні за обома парами патологічних генів?

Answer 1

Ответ:

Глаукома – одно из наиболее тяжелых глазных заболеваний, характеризующееся быстрым прогрессированием и приводящее к необратимой слепоте. Глаукома включает не одно, а группу различных поражений зрительного органа, при которых отмечается постоянное или периодическое повышение внутриглазного давления (ВГД), снижение остроты зрения и атрофия нерва (оптическая нейропатия).

Answer 2

Understanding the Inheritance of Glaucoma

Glaucoma can be inherited in several ways, including through dominant and recessive autosomal genes that are not linked to the sex chromosomes. Let's explore the likelihood of a child being born with the anomaly in the given scenario.

Inheritance Patterns: Glaucoma can be inherited through dominant and recessive autosomal genes. Dominant inheritance means that only one copy of the gene is needed for the trait to be expressed, while recessive inheritance requires two copies of the gene for the trait to be expressed.

Given Scenario: In this case, both parents are carriers of the pathological genes for glaucoma.

Calculation of Probability: To calculate the probability of their child having the anomaly, we can use Punnett squares to visualize the possible genetic combinations.

Dominant Inheritance: If one parent has a dominant gene for glaucoma (G) and the other parent is a carrier (g), the possible combinations for their child would be: - 50% chance of inheriting the dominant gene (Gg) and expressing the trait. - 50% chance of inheriting the carrier gene (gg) and being a carrier without expressing the trait.

Recessive Inheritance: If both parents are carriers with a recessive gene for glaucoma (g), the possible combinations for their child would be: - 25% chance of inheriting two recessive genes (gg) and expressing the trait. - 50% chance of inheriting one recessive gene (Gg) and being a carrier without expressing the trait. - 25% chance of inheriting the dominant gene (GG) and not expressing the trait.

Conclusion: In both scenarios, there is a possibility of the child inheriting the anomaly, with varying probabilities based on the inheritance pattern.

Probability Calculation: The probability of the child having the anomaly can be calculated based on the specific inheritance pattern and the genetic makeup of the parents.

Note: It's important to consult with a genetics professional for a comprehensive understanding of the inheritance patterns and associated risks.