Question

Пользуясь таблицейгенетического кода,определите,как изменитсяструктура белка,кодируемоготакой последовательностьюнуклеотидов вДНК:ТТТГГГ ЦЦЦАААЦГААГГАТТТАА ЦЦЦГЦГ,если произошламутация,в результате которойучасток с3-го по7-йнуклеотидбыла повторенадважды.

Answer 1

ДНК до мутации:     3'-ТТТ ГГГ ЦЦЦ ААА ЦГА АГГ АТТ ТАА ЦЦЦ ГЦГ-5'

ДНК после мутации:3'-ТТТ ГГГ ЦТГ ГГЦ ЦЦА ААЦ ГАА ГГА ТТТ ААЦ ЦЦГ ЦГ-5'

иРНК :                    3'-ААА ЦЦЦ ГАЦ ЦЦГ ГГУ УУГ ЦУУ ЦЦУ ААА УУГ ГГЦ ГЦ -5'

Структура белка:       -ЛИЗ-ПРО-АСП-ПРО-ГЛИ-ЛЕЙ-ЛЕЙ-ПРО-ЛИЗ-ЛЕЙ-ГЛИ-

Answer 2

Determining the Protein Structure from DNA Sequence

To determine how the protein structure encoded by a DNA sequence will change due to a mutation, we need to understand the genetic code and the effect of the mutation on the DNA sequence.

The genetic code is a set of rules that determines how the sequence of nucleotides in DNA is translated into the sequence of amino acids in a protein. Each three-nucleotide sequence, called a codon, corresponds to a specific amino acid or a stop signal.

In this case, we have the DNA sequence: ТТТГГГ ЦЦЦАААЦГААГГАТТТАА ЦЦЦГЦГ. Let's break it down and analyze the mutation.

The DNA sequence can be divided into three parts: 1. ТТТГГГ: This sequence corresponds to the codons for the first part of the protein. 2. ЦЦЦАААЦГААГГАТТТАА: This sequence corresponds to the codons for the second part of the protein. 3. ЦЦЦГЦГ: This sequence corresponds to the codons for the third part of the protein.

Now, let's analyze the mutation that occurred in the DNA sequence. The mutation involves a duplication of the nucleotides from the 3rd to the 7th position. This means that the sequence "ЦЦЦАААЦГААГГАТТТАА" is duplicated.

To determine the effect of this mutation on the protein structure, we need to consider the resulting changes in the amino acid sequence.

Let's break down the DNA sequence into codons and determine the corresponding amino acids for each codon:

1. ТТТ: This codon corresponds to the amino acid Phenylalanine. 2. ГГГ: This codon corresponds to the amino acid Glycine.

The duplicated sequence "ЦЦЦАААЦГААГГАТТТАА" corresponds to the following codons and amino acids:

1. ЦЦЦ: This codon does not correspond to any amino acid and is likely a sequencing error or an unknown codon. 2. ААА: This codon corresponds to the amino acid Lysine. 3. ЦГА: This codon corresponds to the amino acid Arginine. 4. ААГ: This codon corresponds to the amino acid Lysine. 5. ГГА: This codon corresponds to the amino acid Glycine. 6. ТТТ: This codon corresponds to the amino acid Phenylalanine. 7. ТАА: This codon corresponds to the amino acid Stop.

Therefore, the duplicated sequence "ЦЦЦАААЦГААГГАТТТАА" results in the addition of the amino acids Lysine, Arginine, Lysine, Glycine, Phenylalanine, and a stop signal to the protein.

The resulting protein structure will have an additional segment of amino acids due to the duplication mutation.

Please note that the unknown codon "ЦЦЦ" in the duplicated sequence may indicate a sequencing error or an unknown codon. It is important to verify the accuracy of the DNA sequence and consult additional sources or experts for further analysis.

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